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Pradeep Kumar, Y.
- A Review on 1,3,4-Thiadiazoles
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Authors
Affiliations
1 Dept. Of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa, 516150
1 Dept. Of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa, 516150
Source
Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 272-277Abstract
Heterocyclic compounds occupy a central position among those molecule that makes life possible. The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes constituents an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. During the recent years there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities. Among of these compounds having1,3,4,- thiadiazole nucleus are known to exhibit unique Antioxidant/radio protective activity, In vitro inhibition of cyclo oxygenase and 5-lipoxygenase activities, Molluscicidal activity, Carbonic anahydrase inhibitors, Anti-cancer activity, Anti convulsant activity ,Antifungal activity, Anti bacterial activity, Anti cholinergic activity, Anti histaminic activity, Anti-depressant activity, Anti-tuberculosis activity The present review highlights the recently synthesized thiadiazole possessing important biological activitiesKeywords
1,3,4-thiadiazoles, Anti Fungal Activity, Molluscicidal Activity, Carbonic Anahydrase Inhibitors, Anticancer Activity, Anti Convulsant Activity
References
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- A Review on 1,3-Thiazolidin-4-Ones
Abstract Views :1367 |
PDF Views:3
Authors
Kencha Swathi
1,
M. Sreenivasulu
2,
T. Hari Narayana Reddy
1,
Y. Pradeep Kumar
1,
G. Mahaboob Basha
1
Affiliations
1 Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
2 Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
1 Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
2 Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh
Source
Asian Journal of Research in Chemistry, Vol 6, No 10 (2013), Pagination: 879-887Abstract
1,3-Thiazolidin-4-ones are important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. This review aims to review the work reported on the chemistry and biological activities of 1,3- thiazolidin-4-ones during the past few years. Since a decade extensive research work is undergoing on the thiazolidine ring. Researchers have developed number of new compounds related to1,3-thiazolidin-4-ones further they have screened them for various pharmacological activities to get a molecule with good pharmacological activities and with least adverse effects. The thiazolidine is not only synthetically important scaffold but also possesses a wide range of promising biological activities. Some thiazolidine derivatives have better activity than standard drug and could become a new drug for the market in future. This thiazolidine moiety and its derivatives has shown its importance as antimicrobial, anti-bacterial, anti-tubercular, anti-fungal, anti-inflammatory, analgesic, anti-cancer, anti-proliferative, anti- HIV, anti-retroviral,anti-yellowfevervirus,anti-diarrhoeal,anti-arrythmic agent, anti-convulsant, anti-oxidant, antimalarial.Keywords
Thiazolidinone, Biological Activities, Anti-microbial, Anti-malarial, Future AspectReferences
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- Synthesis, Characterization, Docking and Biological Evaluation of Tetra Hydro Imidazo [1, 2-A] Pyrazine Derivatives
Abstract Views :188 |
PDF Views:2
Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole, 523272, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet, 516126, IN
3 Dept. of Pharmacognosy, Annamacharya College of Pharmacy, Rajampet, 516126, IN
1 Dept. of Pharmaceutical Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole, 523272, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet, 516126, IN
3 Dept. of Pharmacognosy, Annamacharya College of Pharmacy, Rajampet, 516126, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 6 (2016), Pagination: 271-276Abstract
Novel Tetra hydro imidazo[1,2-a] pyrazine derivatives have been synthesized by Treatment of pyrazine-2- carboxylic acid with thionyl chloride in methanol yielded methyl pyrazine-2-carboxylate.This up on treatment with alcoholic ammonia gave pyrazinamide, further it was undergone Hoffman's degradation, gave 2-amino pyrazine after that it was refluxed for 26 hrs with chloro acetaldehyde , sodium bicarbonate gave imidazo[1,2-a] pyrazine and hydrogen gas was passed on it in the presence of palladium on carbon yielded tetra hydro imidazo[1,2-a] pyrazine ,which was treated with different substituent's to get the novel derivatives. Synthesized compounds were identified and characterized by Melting point, TLC, FT-IR, 1H and 13C NMR , MASS and percent purity done by HPLC . Based on characterization and percent purity novel derivatives were subjected for molecular docking , QSAR studies and pharmacological evaluation. Selected compounds were docked on Antioxidant activity using "Thioredoxin peroxidase B" as a target site. QSAR parameters like partition coefficient was studied and showed polar surface area below 140 A0 and passed ADME parameters. Analysis of docking and QSAR studies suggested that remarkable inhibitory activity was exhibited by the derivatives. Hydrogen bond interactions were mapped to confirm their potencies. They were evaluated for In-Vitro Anti-oxidant activity by DPPH method and In-Vitro Anti-diabetic activity by alpha-amylase inhibition assay by DNSA method. Results suggested that electron withdrawing groups like nitro, bromo having compounds shown potent activity. Rest of compounds showed mild to moderate activity.Keywords
Tetra Hydro Imidazo[1,2-A] Pyrazine, Docking and Q SAR, Anti-Oxidant, Anti-Diabetic Activities.- Synthesis, Characterization of 3-chloro 4-(4- Substituted Phenyl -1- (4- Nitro Phenylazetidin -2-one by Microwave Method and Evaluation of their Antibacterial Activity
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Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
1 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN